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Polynucleotides vs Profhilo: Which is right for you?

Polynucleotides Treatment, Waltham Abbey, Essex

If you’re considering skin rejuvenation or anti-ageing treatments, you have likely come across two popular injectables: Polynucleotides and Profhilo. And you may now be wondering what the difference is between the two. Even though both treatments work to improve the skin’s appearance and condition, they are actually quite distinct from each other in terms of how they work and the results they have. If you’re wondering what is right for you, read on to understand what each treatment is, how it should be used, and what to expect in terms of results to help you make an informed decision.

A deeper dive into Profhilo…

Profhilo is a revolutionary treatment in the field of aesthetics, particularly known for its biomodelling properties. Unlike dermal fillers, which simply add volume, Profhilo works to hydrate the skin from within and stimulate collagen and elastin production. It is composed of high concentrations of hyaluronic acid (HA), a naturally occurring substance in the body that retains moisture and supports the skin’s structure.

How does Profhilo work?

Profhilo is administered through a series of small injections into the superficial layers of the skin. Once injected, the high levels of hyaluronic acid spread evenly throughout the skin, attracting water and providing intense hydration. This not only plumps up the skin but also stimulates the natural production of collagen and elastin, leading to improved skin texture, firmness, and elasticity over time. The treatment is typically carried out in two sessions spaced about four weeks apart, and the results can last up to six months.

Is Profhilo right for you?

Profhilo is suitable for individuals who are experiencing signs of ageing such as fine lines, wrinkles, and sagging skin, particularly on the face, neck, and hands. It is ideal for those looking for a natural improvement in skin quality without the adding volume. The treatment is minimally invasive with little to no downtime, making it a popular choice for those with busy lifestyles.

Exploring polynucleotides…what exactly are they?

Polynucleotides, on the other hand, are a newer addition to the world of aesthetics but are gaining popularity due to their regenerative properties. Polynucleotides are fragments of DNA that have the ability to repair and rejuvenate the skin at a cellular level. These treatments focus on stimulating tissue regeneration, improving skin elasticity, and providing deep hydration.

How do they work?

Polynucleotide treatment involve injecting these DNA fragments into the dermal layers of the skin. Once in the skin, polynucleotides work by promoting fibroblast activity, which enhances collagen production and improves the overall structure and elasticity of the skin. Additionally, polynucleotides have a powerful anti-inflammatory effect, which helps in reducing redness and swelling. This dual action of regeneration and inflammation reduction makes it an excellent choice for skin repair and rejuvenation. The treatment protocol usually requires a series of sessions for optimal results.

Are polynucleotides right for you?


Polynucleotide treatments are suitable for anyone who has damaged or ageing skin and are looking for a way to rejuvenate and repair it at a deeper level. It is particularly beneficial for those who have skin conditions such as acne scars, rosacea, or sun damage. Additionally, individuals who have thin, fragile skin can benefit from the strengthening and thickening effects of polynucleotides.


So, how do polynucleotides and Profhilo compare?


When considering which may be right for you, it’s essential to consider your specific skin concerns and desired outcomes. Profhilo excels in providing intense hydration and stimulating collagen and elastin production, which results in smoother, firmer skin. It’s an excellent option for those who want a natural-looking enhancement with minimal downtime.


On the other hand, Polynucleotides offer a more regenerative approach, repairing and rejuvenating the skin at a cellular level. This makes it a better choice for individuals with more significant skin damage or those looking to address specific conditions such as scars, pigmentation or rosacea.


Both treatments require multiple sessions for the best results and have minimal side effects and downtime. However, the choice between the two should be guided by your specific skin needs and the recommendations of a qualified aesthetic practitioner.


Which treatment is right for you?


Deciding between Polynucleotides and Profhilo ultimately comes down to your individual skin concerns and goals. If your primary focus is on hydration, improving skin texture, and achieving a subtle, natural enhancement, Profhilo might be the ideal choice for you. Its ability to provide a youthful glow and firmness makes it popular among those looking to counteract the early signs of aging.


However, if you are dealing with more pronounced skin issues such as scars, significant sun damage, or a need for deeper regenerative effects, Polynucleotides could be the better option. Their ability to repair and rejuvenate the skin at a cellular level makes them a powerful treatment for more advanced skin concerns.


While Profhilo is not suitable for use around the eyes, polynucleotides can be effectively applied in this area. Therefore, if you are concerned about wrinkles, laxity, dark circles, or crepeyness around the eyes, polynucleotides may be the better option for you.


Polynucleotides and Profhilo offer unique benefits and can significantly improve skin quality. Consulting with a qualified aesthetic practitioner can help determine the best treatment plan tailored to your skin’s specific needs.


If you’d like to explore the options, and understand what’s right for you, click here to enquire to book a consultation.

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